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OpenAI published a safety addendum Friday for GPT-Rosalind-6, a biology and drug-discovery model offered only through its trusted-access program to vetted scientists, institutes, companies and government biodefense teams.
It uses the same as GPT-6 Astra with no further training, configured to refuse fewer dual-use biology questions.
OpenAI rates it High in biological and chemical capability, below Critical, and Critical for cybersecurity.
Against GPT-Rosalind-5.5 it scores 49.6% against 28.9% on MedChemBench, 37.7% against 16.7% on GeneBench Pro and 61.3% against 44.0% on LifeSciBench, all OpenAI's figures.
None of its four Critical-level biology evaluations crossed its threshold.
Approved customers must restrict access to named users and have qualified people review outputs before they shape experiments or publications.
OpenAI opens GPT-Rosalind-6 to vetted labs, with fewer refusals on dual-use biology
OpenAI published a safety addendum Friday for GPT-Rosalind-6, a biology and drug-discovery model offered only through its trusted-access program to vetted scientists, institutes, companies and government biodefense teams. It uses the same weights as GPT-6 Astra with no further training, configured to refuse fewer dual-use biology questions. OpenAI rates it High in biological and chemical capability, below Critical, and Critical for cybersecurity.
Against GPT-Rosalind-5.5 it scores 49.6% against 28.9% on MedChemBench, 37.7% against 16.7% on GeneBench Pro and 61.3% against 44.0% on LifeSciBench, all OpenAI's figures. None of its four Critical-level biology evaluations crossed its threshold. Approved customers must restrict access to named users and have qualified people review outputs before they shape experiments or publications. SourcesA
Sources
- AGPT-Rosalind-6 system card addendum (OpenAI)deploymentsafety.openai.com
This story ran in the Afternoon Brief of October 31st 2026.